MULTI-FUNCTIONAL ELECTROSPUN SCAFFOLDS Diverse microstructures Mechano- and/or electro-active cell/tissue scaffolds Electrospinning process showing ejected polymer jets from a needle Diverse morphologies of electrospun scaffolds ENGINEERING CELLULAR MICROENVIRONMENTS Guided stem cell differentiation Enhanced cell functionality SEM image of a 3D induced pluripotent stem cell colony on an electrospun scaffold Confocal IF image of a 3D induced pluripotent stem cell colony on an electrospun scaffold FUNCTIONAL TISSUE MORPHOGENESIS Osteochondral tissue engineering by mechano-stimulation Nerve regeneration by piezoelectrical stimulation An engineered osteochondral interface with cartilage (top) and bone (bottom) phases An engineered neural tissue with ~ 0.5 mm neurite extension